These technical Guidelines are intended as a contribution to the implementation of Agenda 21 commitments and aim to assist Governments, intergovernmental, private-sector and other organizations in the establishment and maintenance of national capacities to provide for safety in biotechnology, to assist in developing expert human resources and for international exchange of information.  These Guidelines have been developed on the basis of common elements and principles derived from relevant existing regional and international instruments and national regulations and guidelines, and drawing upon experience already gained through their preparation and implementation.